Mandana Pahlavani, Ph.D.

Assistant Professor

Nutrition and Food Sciences

Mandana Pahlavani, Ph.D.

Contact

mpahlavani@twu.edu
940-898-2650
SRC 204I

View CV

Biography

Mandana Pahlavani, Ph.D. is an Assistant Professor of Nutrition at Texas Woman's University in Denton, Texas. She has a strong research background in areas of Nutrition, Obesity, Cardiometabolic health, and Inflammation. Her doctoral research focused on determining mechanisms by which omega 3 fatty acids (n-3) polyunsaturated fatty acids, primarily eicosapentaenoic acid (EPA), activate brown adipose tissue and induce the thermogenic marker, uncoupling protein-1 (UCP-1) to reduce obesity. She was awarded a United States Department of Agriculture (USDA) Postdoctoral Fellowship to investigate gene and miRNA analyses of mechanisms mediating anti-inflammatory effects of fish oil and dose-dependent effects of fish oil in obesity. Her second postdoc at UT Southwestern Medical Center (UTSW), supported by the NIH T32 training program focuses on patient-oriented research in cardiometabolic health. She was awarded American Heart Association (AHA) Postdoctoral Fellowship to perform deep phenotyping approaches to understand the role of lipid metabolism in cardiometabolic health. Her current research investigates the link between extreme cholesterol efflux capacity (CEC), anti-inflammatory, and antioxidant functions of HDL in a diverse cohort of Dallas Heart Study. In addition, she will investigate the use of bioactive food compounds and nutrients such as polyphenols, antioxidants, and functional foods in reducing cardiovascular disease (CVD), obesity, and inflammation.

Education

Ph.D., Nutritional Sciences, Texas Tech University, Lubbock, TX
M.S., Food Science and Technology, Ferdowsi University of Mashhad, Mashhad, Iran
B.S., Food Science and Technology, Urmia University, Urmia, Iran

Research Interests

HDL Function; Inflammation and Atherosclerosis Bioactive Food Compounds; Obesity; Cardiovascular Disease; Inflammation

Latest Articles

Sex-dependent effects of Eicosapentaenoic acid and UCP1 deficiency on hepatic steatosis in diet-induced obese mice
Current Developments in Nutrition (2021)
K Albracht-Schulte, S Wilson, P Johnson, Mandana Pahlavani, L Ramalingam

Uncoupling Protein 1-Independent Effects of Eicosapentaenoic Acid in Brown Adipose Tissue of Diet-Induced Obese Female Mice
Journal of Nutritional Biochemistry (2021)
Emily K Miller, Mandana Pahlavani, Latha Ramalingam, Shane Scoggin, Naima Moustaid-Moussa

Molecular Patterns of Extreme and Persistent Cholesterol Efflux Capacity
Arteriosclerosis Thrombosis and Vascular Biology (2021)
Ayea El-Ghazali, Sneha Deodhar, Suzanne Saldanha, Brooke Smyth, Mark Izbrand

Discordant dose-dependent metabolic effects of Eicosapentaenoic acid in diet-induced obese mice
Nutrients (2020)
Mandana Pahlavani, L Ramalingam, E Miller, H Davis, S Scoggin

Eicosapentaenoic acid reduces adiposity, glucose intolerance and increases oxygen consumption independently of UCP1
Molecular Nutrition and food research (2019)
Mandana Pahlavani, L Miller, E Miller, S Scoggin, K Menikdiwela

Eicosapentaenoic acid regulates inflammatory pathways through modulation of transcripts and miRNA in adipose tissue of obese mice
Biomolecules (2019)
T Ramalho, Mandana Pahlavani, N Kalupahana, N Wijayatunga, L Ramalingam

An integrative transcriptomic approach to identify differentially expressed genes and miRNAs in visceral, subcutaneous, and brown adipose tissue from high fat fed mice
Oncotarget (2018)
N Wijayatunga, Mandana Pahlavani, R Kottapalli, P Kottapalli, L Ramalingam

Transcriptomic and microRNA analyses of gene networks regulated by Eicosapentaenoic acid in brown adipose tissue of diet-induced obese mice
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (2018)
Mandana Pahlavani, N Wijayatunga, R Kottapalli, L Ramalingam, P Gunaratne

Adipose tissue inflammation in insulin resistance: review of mechanisms mediating anti-inflammatory effects of omega-3 polyunsaturated fatty acids
Journal of Investigative Medicine (JIM) (2017)
Mandana Pahlavani, T Ramalho, I Koboziev, M LaMieux, S Jayarathne

Regulation and functions of the renin-angiotensin system in white and brown adipose tissue
Comprehensive Physiology (2017)
Mandana Pahlavani, N Kalupahana, L Ramalingam, N Moustaid-Moussa

Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat- fed mice and in clonal brown adipocytes
Journal of Nutritional Biochemistry (2017)
Mandana Pahlavani, F Razafimanjato, L Kalupahana, S Moussa, H Moussa

Externally Funded Projects

The Role of Inflammation and Oxidation in Impaired Reverse Cholesterol Transport: A Translational Approach
American Heart Association (AHA) Postdoctoral Fellowship | $141,000.00 | 2022
Role: Principal Investigator

Integrated gene and microRNA networks mediating anti-inflammatory effects of omega 3 fatty acids in diet-induced obesity
United States Department of Agriculture (USDA), National Institute of Food and Agriculture (NIFA), Postdoctoral Fellowship | $165.00 | 2018
Role: Principal Investigator

Professional Affiliations

  • American Association for the Advancement of Science (AAAS)
  • American Heart Association (AHA)
  • American Society for Nutrition (ASN)
  • American Society of Biochemistry and Molecular Biology (ASBMB)
  • The Obesity Society (TOS)