Sushmita Sinha, Ph.D.

Assistant Professor

Sushmita Sinha, Ph.D.

SRC 304I


Sushmita Sinha is an Assistant Professor at the Biology Department at Texas Women's University. She completed post-doctoral training at the Oregon health and Science University and at the UT Southwestern Medical Center. After working at the University of Iowa, Dr. Sinha joined the faculty at TWU. The major goal of her lab is to understand the regulation of effector responses from human T-cells with the focus of finding novel therapeutic targets for autoimmunity.


Ph.D., Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
M.Sc., Biotechnology, Dr BR Ambedkar University, Agra, India

Research Interests

Immunology; Immune Dysregulation; Autoimmunity

Latest Articles

Altered expression of SIRPg on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells.
PLoS ONE (2020)
Sushmita Sinha, Renavikar PS , Crawford MP , Tsalikian E , Tansey M

IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation
Frontiers in Immunology (2020)
Pranav S Renavikar, Sushmita Sinha, Ashley A Brate, Nicholas Borcherding, Michael p Crawford

CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL17: Effector resistance to immune suppression.
Proceedings of the National Academy of Sciences (2020)
Michael P Crawford, Sushmita Sinha, Renavikar PS , Borcherding N , Karandikar NJ

Autoimmunity-associated intronic SNP (rs2281808) detected by a simple phenotypic assay: Unique case or broader opportunity?
Clinical Immunology (2019)
Sushmita Sinha, Renavikar PS , Crawford MP , Rodgers JW , Tsalikian E

Autoimmune disease risk SNP rs2281808 in Sirpg is associated with heightened effector state and greater cytotoxic potential in human CD8 T-cells.
Scientific Reports (2018)
Sushmita Sinha, Borcherding N , Renavikar PS , Crawford MP , Tsalikian E

Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen
Scientific Reports (2017)
Farah Itani, Sushmita Sinha, Ashley A Brate, L L Pewe

Current Projects

Despite extensive research, the etiology and underlying immune mechanisms responsible for precipitating autoimmunity remain poorly understood. Genetic risk variants identified by GWAS studies provide novel clues regarding pathogenic mechanisms in autoimmune diseases, however, in most cases the biological consequence of the risk variants and the mechanisms by which they potentiate autoimmunity remains unknown. We focus on Signal Regulatory Protein gamma (SIRP) due to 1) its putative association with Type 1 diabetes (T1D) by multiple GWAS studies 2) our novel preliminary finding that two T-cell mediated autoimmune diseases relapsing remitting multiple sclerosis (RRMS) and T1D (Clin Immunol 2019; PLOS One 2020) showed a significantly greater preponderance of T-cells with abnormally reduced SIRP. SIRP is expressed by both CD4 and CD8 T-cells in humans, however, the role of SIRP and its potential contribution to autoimmunity remains unknown. My research program is focused on two interconnected themes: 1) to understand the role of SIRP in regulating effector T-cell responses in healthy immune system; and 2) to identify the mechanisms by which abnormal reduction in SIRP expression on T-cells predisposes/ potentiates autoimmunity.

Internally Funded Projects

Research enhancement award
Texas Woman's University | $10,000.00 | 2020
Research Grant

Research enhancement award FA2020
Texas Woman's University | $10,000.00 | 2020
Research Grant